Sequence-controlled RNA self-processing: computational design, biochemical analysis, and visualization by AFM

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SCHEME 1.
SCHEME 1.

Hairpin ribozyme mechanism (from left to right) nucleophilic attack followed by intermediate formation and release of newly formed 5′- and 3′-termini (see text for details); (R1, R2) oligonucleotide chain, (B1, B2) nucleobase, (A) acid, (B−) base.

This Article

  1. Published in Advance May 21, 2015, doi: 10.1261/rna.047670.114 RNA 21: 1249-1260

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