Model of OLR1 AS regulation. (A) The identity of the nucleotide in SNP rs3736234 has strong effects on exon 5 inclusion (increased inclusion upon C→T), while the rest of the SNPs in the linkage disequilibrium block attenuate the strong effects of this substitution. (B) Association of SRSF1 to a potential binding site adjacent to rs3736234 promotes exon 5 inclusion. The presence of a C at rs3736234 appears to repress the association of SRSF1 with the adjacent intronic enhancer, leading to higher levels of exon skipping. SRSF2 and HMGA1 may mediate these repressive effects, and while HMGA1 associates with the C-version of the rs3736234 region, SRSF2 likely acts through additional binding sites.
