Yes, SiR
- Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093-0651, USA
- Corresponding author: xdfu{at}ucsd.edu
This extract was created in the absence of an abstract.
How time flies! It is the 20th anniversary of RNA. For many of us, our research career is largely co-incident with the launch and progression of the journal, which has provided bonds and guiding lights for our community. Here, I share my personal experience in entering this exciting RNA world through contributing to the discovery of SR proteins in pre-mRNA splicing, and emphasize that, while a large array of principles have been established for the function of SR proteins in the past two decades, there are still many outstanding questions on the roles of SR proteins in diverse regulatory activities in mammalian cells.
A personal roller coaster in the race to discover the SR family
With the establishment of the in vitro splicing system in early '80s, the machinery for the spliceosome was quickly shown to consist of 5 small nuclear ribonucleoprotein particles (snRNPs), two of which (U1 and U2) are directly responsible for defining the 5′ and 3′ splice sites …
