Reflections for the 20th anniversary issue of RNA journal
- Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 3E1
- Corresponding author: b.blencowe{at}utoronto.ca
This extract was created in the absence of an abstract.
The 20 years since the launch of the RNA journal have seen numerous remarkable advances in RNA research. Those that have had a transformative impact on biomedical research as a whole include the discovery of large repertoires of short and long non-coding RNAs and their widespread roles in normal and disease biology, and the development of powerful methods for manipulating the expression and function of individual genes, based in part on the former discoveries, as well as the more recent development of RNA-guided genome editing tools.
In parallel with these discoveries, and similarly impacting our understanding of essentially every biological process and pathway, has been the illumination of entire landscapes of RNA processing events through the development and application of high-throughput profiling technologies. This work has led to a fundamental rethinking of the nature of biological complexity and diversity, as well as the organization, regulation, function and evolution of biological …
