Pre-mRNA splicing: from protein-coding to noncoding RNAs
- Institute of Biochemistry, University of Giessen, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany
- Corresponding author: Albrecht.Bindereif{at}chemie.bio.uni-giessen.de
This extract was created in the absence of an abstract.
Pre-mRNA splicing in the 1980s and 1990s
Since I started in the pre-mRNA splicing field about three decades ago, I will beginn my little historical recollection at a somewhat earlier time than when the RNA journal started. To keep this somehow organized, I will summarize in decades, starting with the 1980s. What were significant changes in the RNA field over the past few decades? All of that from a very personal perspective.
My own research interests focus on mRNA splicing in the mammalian system and in trypanosomes. Although the balance between these two areas has changed over the years, it has been very rewarding, working in parallel on two widely different, evolutionarily very distant systems.
I was introduced to mRNA processing as a postdoc in Michael Green's laboratory (1984–88), at that time still a very small group at Harvard. Coming from my Ph.D. studies at UC Berkeley on the molecular biology of iron metabolism in bacteria, I …
