Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA

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FIGURE 2.
FIGURE 2.

Identification of arginine methylation of SFPQ/PSF. (A) Dimethylation (R) and both mono or dimethylation (R) sites are mapped on the primary sequence of SFPQ. (B) ETD MS/MS fragmentation spectra of the heavy methylated peptide SR(aDMA)GGGGGGFHR [M+3H]3+. (C) ETD MS/MS fragmentation spectra of the heavy methylated peptide FR(MMA)SR(aDMA)GGGGGGFHR [M+3H]3+. The prominent c, z ions and the characteristic neutral losses associated with asymmetric dimethylation are highlighted (aDMA) dimethylamine, (MMA) monomethylarginine.

This Article

  1. Published in Advance January 20, 2015, doi: 10.1261/rna.045138.114 RNA 21: 347-359

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