Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for mRNA

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FIGURE 5.
FIGURE 5.

Line plot of scaled protein level for two miRNA, noncompetitively interacting with single mRNA. Lines represent specific parts of Supplemental Figure S3. For every constant level of b12p increase in rate of miRNA formation b2μ leads to decrease in protein ratio levels. Other parameter values are constant, given in Table 2.

This Article

  1. Published in Advance January 9, 2015, doi: 10.1261/rna.046862.114 RNA 21: 307-319

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