Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano

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FIGURE 1.
FIGURE 1.

Ago/PIWI proteins are present in M. lignano. (A) Protein sequence alignment of Macpiwi1, Macpiwi2, and Macpiwi3 catalytic triads, DDH. Arrows point to the catalytic residues. Identical (white letters on a red background) or similar (red letters on a white background) residues are labeled. (B) A phylogenetic tree depicting the relationship between Ago/PIWI proteins in M. lignano (red), C. elegans (blue), S. mediterranea (orange), D. melanogaster (green), A. californica (purple), Dugesia japonica (brown), and Homo sapiens (black).

This Article

  1. Published in Advance August 31, 2015, doi: 10.1261/rna.052456.115 RNA 21: 1885-1897

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