Gene Ontology analysis of human RBPs with multiple RRMs. (A) Sibling RRMs with different similarities tend to bind distinct regions of mRNA. The similarities between sibling RRM pairs are represented with a histogram (gray), with the colored dots indicating the gene ontology (GO) terms enriched in the genes from different bins of the histogram. (B) According to the domain similarity score between sibling RRMs, all RBPs were divided into six groups as equally as possible: 1–20 (108 pairs), 21–24 (92 pairs), 25–28 (106 pairs), 29–33 (104 pairs), 34–41 (97 pairs), and 42–100 (93 pairs). The GO analyses were carried out, and the enriched functional terms in each bin are represented with a heat map to indicate the significance of enrichment. The functions common to all groups are marked.
