miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

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FIGURE 7.
FIGURE 7.

Predicted structures of wild-type and modified hairpins of hsa-mir-145, hsa-mir-137, hsa-mir-9-1, and hsa-mir-200b, demonstrating canonical “mismatched” and “rigid” miRNA hairpins. Entropy curves of the nucleotide sequence, starting at the 5′ end, indicate stability changes being local to the changed regions.

This Article

  1. Published in Advance March 27, 2014, doi: 10.1261/rna.043943.113 RNA 20: 621-631

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