FIGURE 2.
Composition of peptoid libraries. (A) The combinatorial peptoid libraries spotted to microarrays comprised four variable peptoid monomers and a central constant guanidinium-bearing peptoid side chain. The wavy line indicates the position of attachment to the array surface. (B) Amines used in library synthesis, shown with the substituents as they are after de-protection to illustrate the composition of the final library. The amine groups are incorporated into the amide backbone during peptoid synthesis. (C) Conjugation of propargyl side chains with phenylboronic acid to create Sublibrary B using copper-catalyzed 1,3-dipolar cyclo-addition.
