An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 7.
FIGURE 7.

Cation binding sites in Lys1.2minE. (A) Coordination geometry of Na+ to surrounding atoms that stabilize loops 1 and 2. (B) The effect of monovalent cation type on lysozyme affinity. (C) Locations of the two ordered Mg2+ ions in the regions of the most negative electrostatic potential in the loops of the RNA. Water molecules are depicted as purple spheres.

This Article

  1. Published in Advance February 25, 2014, doi: 10.1261/rna.043034.113 RNA 20: 447-461

Current Issue

  1. July 2026, 32 (7)
  1. Current Issue
  1. Alert me to new issues of RNA