An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates

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FIGURE 6.
FIGURE 6.

The lysozyme–Lys1.2minE interface. (A) The anionic phosphates of A31 and A35 bind with positively charged side chains of Lys1 and Arg5. (B) The binding surface area (highlighted in pink) is surprisingly small in comparison to other protein–RNA aptamer complexes. (C,D) Eight water molecules (red spheres) coordinate lysozyme residues with minE bases at the binding interface.

This Article

  1. Published in Advance February 25, 2014, doi: 10.1261/rna.043034.113 RNA 20: 447-461

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