Differentially expressed snoRNAs in young 3xTG AD mice. (A) Candidate e307: sequence similarity of mouse (mm9 assembly) to the human (hg19 assembly) snoRNA homologs (located on chromosome 5), and (left) predicted secondary structure illustrated by VARNA (http://varna.lri.fr/). (Right) Northern blot analysis of e307 from total RNA of cortices of 10-mo-old 3xTG mice compared with wild-type controls. (B) Candidate e470: genome positions of the two (red and green bars) potential loci of transcription (on chromosome 5), which differ by a single SNP (indicated in bold). Sequence similarity of HBII-336 and MBII-336; (left) predicted secondary structure illustrated by VARNA. (Right) Northern blot analysis from total RNA of cortices of 10-mo-old 3xTG mice compared with wild-type controls. C/D boxes are illustrated in red and sequences targeted by the oligonucleotide from the microarray e307 and e470, respectively, are highlighted in blue.
