Differential expression of ncRNAs from cortices of a triple-transgenic (3xTG) mouse model for Alzheimer's disease (Oddo et al. 2003) compared with wild-type controls at the age of 3, 10, and 20 mo, respectively. (A) Box plots represent fold changes of ncRNAs (colored data points), which showed significant changes in expression relative to their wild-type controls in microarray experiments. The experiments are illustrated from left to right: 3-, 10-, and 20-mo-old mice. Fold changes are illustrated in log2 scale. Whiskers extend to ±1.5-fold of the interquartile range (IQR). Biotypes are designated by color code: miRNAs (red), snoRNA (orange), tRF (blue), other biotypes (green), and unknown biotype (gray). (B) Venn diagram illustrating the overlap of differentially expressed candidates between the different age groups. (C) Fold change and annotation of ncRNA candidates highlighted in B.
