FIGURE 4.
TATA-box motif-specific miRNAs enhance the promoter activity of many important cellular genes. (A) Predicted interactions between the core promoter of four human genes and four human miRNAs. TATA-box motifs were highlighted. (B) The promoter activities of indicated genes were measured with dual-luciferase assay upon the overexpression of their corresponding miRNAs. The promoter-driven luciferase reporters were transfected into HEK293T cells with synthesized miRNA mimics or miRNA precursors containing construct. P-values were calculated using the two-tailed unpaired Student's t-test with equal variances, n = 3 biological replicates. (*) P < 0.05.
