The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction

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FIGURE 7.
FIGURE 7.

Schematic of the spliceosome catalytic steps showing different chemical reactions that the spliceosome can catalyze. Filled thick arrows represent reactions that require monovalent cations, and open thick arrows represent those that do not require monovalent cations. The double-headed arrow represents competition between R1 and DBR reactions, with conditions favoring one or the other indicated.

This Article

  1. Published in Advance May 16, 2013, doi: 10.1261/rna.038638.113 RNA 19: 971-981

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