The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element

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FIGURE 6.
FIGURE 6.

Amino acid residues required for the Runt domain to recognize DNA or RNA. (A) The secondary structure of RDE and amino acid residues that recognize bases, as determined by crystallography. (Black squares) Highly required amino acid residues; (dashed boxes) partially required amino acids. (Arrows) Direct interactions between an amino acid and a base. (B) The secondary structure of Apt1-S deduced by NMR analysis. (C) The secondary structure of the consensus motif. (Gray boxes) The conserved base pairs and a base.

This Article

  1. RNA 19: 927-936