The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element

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FIGURE 1.
FIGURE 1.

Runt-binding aptamer sequences. (A) RNA sequences selected from 30N and 40N randomized RNA libraries. Parental 30N or 40N sequences contained 5′- and 3′-constant sequences for primer annealing. The frequency of each sequence is shown in the right column as a percentage of the 60 sequences analyzed. (Red) Consensus sequences of aptamers. (B) The consensus sequences. M designates A or C; N designates any base; and N′ designates a base complementary to N. (Red) Conserved bases.

This Article

  1. RNA 19: 927-936