Alternative mRNA isoform changes detected by only either U133 (A) or HuEx (B) platforms. Five of the top alternative isoform usage changes detected by SplicerEX on each platform were examined by plotting the genomic location of all probe sets that overlapped known UCSC gene transcript exons. All such probe sets detected above background are shown above the corresponding known UCSC gene transcripts. The most significant increasing meta-probe set (“UP feature”) (red); the most significant decreasing meta-probe set (“DOWN feature”) (blue); all remaining probe sets (black). U133 specific events (A) were more often located in the 3′-UTR region, where HuEx probe sets were unable to detect transcripts. HuEx-specific events (B) were more often 5′ and internally located, and were not interrogated by U133 probe sets.
