Evaluation of normalization methods in mammalian microRNA-Seq data

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FIGURE 3.
FIGURE 3.

Evaluation of normalization methods with empirical statistics. (Top) Comparison of mean squared errors (or MSE, black bar), as well as the two decomposed forms of MSE, variance (empty bar) and bias (gray bar), in various normalization methods. (Bottom) Comparison of K-S statistics calculated from the M-values before and after different normalization methods. The left plot is based on F-data and the right plot is based on K-data.

This Article

  1. Published in Advance April 24, 2012, doi: 10.1261/rna.030916.111 RNA 18: 1279-1288

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