Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein

Comparison of amino acids surrounding the tyrosine phosphorylation site of xPMR1 with the human peroxidases. The upper panel shows a MEME analysis of the sequences of the 42 human peroxidases and their isoforms across the region corresponding to the tyrosine phosphorylation site of xPMR1 (boxed). The height of each letter corresponds to the relative representation of a given amino acid at a particular site. In the lower panel, the major human peroxidases and the peroxidasins are shown aligned with xPMR1 across the same region. The box indicates the tyrosine residue that corresponds to the phosphorylated tyrosine of xPMR1.