Comparison with the structure of the HAT domain of CstF-77. (A) Schematic drawing of the overlay of the HAT domain dimer structure of K. lactis Rna14 in crystal form 1 (in color) with that of CstF-77 (in gray). The HAT-C domains of monomer 1 are superimposed for this overlay. (B) Large differences in the orientation and position of the HAT-N domains between the structures of Rna14 (green) and CstF-77 (gray), after the HAT-C domains are superimposed. The difference in orientation between the two structures is indicated with the red arrow. (C) Large structural differences between the HAT-C domains of Rna14 (yellow) and CstF-77 (gray), indicated with the red arrows.
