Rationalization and prediction of selective decoding of pseudouridine-modified nonsense and sense codons

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FIGURE 4.
FIGURE 4.

Roles of the A-minor motifs in the decoding recognition. (A) tRNA-mRNA base pairs between tRNAThr(UGU) and ΨAA. (B) tRNA-mRNA base pairs between tRNATyr(GUA) and ΨGA. (C) tRNA-mRNA base pairs between tRNAPhe(GAA) and UUU taken from the crystal structure of 1IBM is also shown for comparison. Distances between C1′ atoms of all base pairs are measured and annotated. Black dotted lines represent hydrogen bonds, and gray lines represent weaker interactions. Carbon atoms are colored in green (for crystal structures) or cyan (modeled structures), nitrogen in blue, oxygen in red, and hydrogen in white.

This Article

  1. Published in Advance January 26, 2012, doi: 10.1261/rna.031351.111 RNA 18: 355-367

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