Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs

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FIGURE 1.
FIGURE 1.

The chemical structure of 1-methyladenosine and human mitochondrial tRNALeu(UUR). (A) Chemical structure of 1-methyladenosine (m1A). (B) Secondary structure of human mitochondrial tRNALeu(UUR) with modified nucleosides: 1-methylguanosine (m1G), 2-methylguanosine (m2G), dihydrouridine (D), pseudouridine (Ψ), 5-taurinomethyluridine (τm5U), 5-methylcytidine (m5C), and 5-methyluridine (m5U). Nucleoside positions are numbered following conventional guidelines (Steinberg et al. 1993).

This Article

  1. Published in Advance October 24, 2012, doi: 10.1261/rna.035600.112 RNA 18: 2269-2276

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