Kinetic analysis of pre-ribosome structure in vivo

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FIGURE 4.
FIGURE 4.

Interactions between U3 snoRNA and the pre-rRNA. (A) U3 interacts with the 5′ ETS at sites around positions +280 and +480 (Beltrame and Tollervey 1995; Dutca et al. 2011), and with the 18S rRNA around +10 and +1140 (Hughes et al. 1987; Sharma and Tollervey 1999; Kudla et al. 2011). (B) Sites of U3 binding along the pre-rRNA. Colors match the rRNA regions highlighted in panel A. (C) U3 interactions detected by CLASH within the 18S rRNA region. (B,C, red) The U3 and rRNA sequences involved in the interaction.

This Article

  1. Published in Advance October 23, 2012, doi: 10.1261/rna.034751.112 RNA 18: 2187-2200

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