A structure-based model of RIG-I activation

5′ppp-dsRNA binding by RIG-I. (A) Ribbon and surface representation of human RIG-I bound to 14-mer dsRNA and transition-state analog ADP:BeF₃ (indicated as ATP) in three orientations (PDB entry 3TMI) (Jiang et al. 2011) color coded as in Figure 1A. (B) Details of the binding of 5′ppp-dsRNA to the human RIG-I CTD (PDB entry 3LRN, chain A) (Lu et al. 2010). (C) Schematic diagram of contacts of various domains and motifs of human RIG-I to dsRNA based on Jiang et al. (2011) and Kowalinski et al. (2011).