A structure-based model of RIG-I activation

The three different structures of RIG-I bound to dsRNA. (A) Human RIG-IΔCARDs with a 10-mer dsRNA but no nucleotide at 2.5 Å resolution (PDB entry 2YKG) (Luo et al. 2011). (B) Human RIG-IΔCARDs complexed with the transition-state analog ADP:BeF₃ and a 14-mer dsRNA at 2.9 Å resolution (PDB entry 3TMI) (Jiang et al. 2011). (C) Duck RIG-IΔCARDsΔCTD in complex with the transition-state analog ADP:AlF₃ and a 19-mer dsRNA at 3.7 Å resolution (PDB entry 4A36) (Kowalinski et al. 2011).