TRBP alters human precursor microRNA processing in vitro

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FIGURE 3.
FIGURE 3.

TRBP inhibits processing of some pre-miRs in a structure-dependent way. (A) TRBP inhibits pre-miR-31 and HL5 processing by Dicer ([Dicer], [Dicer–TRBP] = 5 nM, [RNA] = 50 nM). (B) The effect of cleavage site bulge in pre-miR-31 in Dicer–TRBP processing ([Dicer], [Dicer–TRBP] = 5 nM, [RNA] = 50 nM; graphs represent data from three experimental replicates).

This Article

  1. Published in Advance September 24, 2012, doi: 10.1261/rna.035501.112 RNA 18: 2012-2019

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