Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay

Sequence alignment of the PAM2 motifs. Numbers above the sequences indicate positions in the PAM2 motif (Kozlov et al. 2004). Numbers at both ends of the sequences represent residue numbers in mouse eRF3a/b, human Pan3 (Uchida et al. 2004), Tob (Ruan et al. 2010), and Tob2 (Kozlov et al. 2004). The unconserved residues between eRF3a and b are enclosed by rectangles. (Green) The overlapped residues of eRF3 within 12 residues of PAM2.