Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation

Protein–protein interactions among P-body components. The protein–protein interactions (PPIs) among reported and predicted human P-body components are visualized using Cytoscape. Node colors: (green) NMD factors; (blue) miRNA-mediated gene silencing factors; (magenta) ARE-mediated decay factors; (red) decapping factors; (yellow) deadenylation factors. Lines between the nodes represent PPIs. Details are described in the Materials and Methods.