SID-1 is a dsRNA-selective dsRNA-gated channel

Transport of natural-like RNAs that contain single-stranded RNA regions. (A) Summary of normalized conductance change of SID-1(WT) (circles) or SID-1(S536I) (squares) expressing cells in response to the addition of the indicated nucleic acids (see Fig. 3 legend). *P < 0.001; **P < 0.05 (Kologonov-Smirnoff test) for all results compared to SID-1(S536I) cells exposed to 500-bp dsRNA. (B) Summary of transport and retention properties for the indicated nucleic acids (see Fig. 3 legend). Error bars = 1 standard deviation; P < 0.005, Student's t-test.