Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I

Graphic map of CF I_m59 and CF I_m68 proteins. (A) Domains are indicated by different patterns (see code under C). RRM, RNA recognition motif; Pro-rich, proline–rich domain; GAR, glycine-arginine motif (the box of potential or cryptic GAR is white in CF I_m59 because no methylation was identified); and RS/RD signifies an RS-like domain. Also indicated as insets are included and skipped exons in alternatively spliced forms of CF I_m. (B) The protein sequence of the CF I_m68 fragment in the GST-68_GR clone and with the exon included (in parentheses) in GST-68L1_GR. (C) Fragments of CF I_m59 and CF I_m68 used in the experiments. Protein segments are not drawn to exact scale.