Genes containing MIR155 seed sequences are enriched in down-regulated fractions. Relative expression (expression in MIR155 transduced Mutu I cells divided by the expression in control transduced Mutu I cells) histograms for genes containing 7-mer or 8-mer (A), 8-mer (B), or 7-mer (C) seeds in their 3′ UTR. (D) Cumulative distribution of genes with different seed classes. P-values for all seed classes as determined by one-sided Wilcoxon test (Wil.) and one-sided Kologorov–Smirnov test (K-S) were <2.2 × 10−16. (E) Cumulative distribution of genes with different numbers of seeds. P-values for all seed number comparisons were determined using a one-sided Wilcoxon test and a one-sided Kologorov–Smirnov test and are shown in the matrix to the right.
