Autoregulation of Fox protein expression to produce dominant negative splicing factors

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FIGURE 8.
FIGURE 8.

Diagram of the regulation of Fox expression and activity through splicing of the alternative RRM exon. Fox pre-mRNA, mRNA, and protein isoforms are shown from left to right. The alternative exon, encoding the second half of the RRM motif is shown as a gray box, its flanking constitutive exons as open boxes. The blunt arrows indicate an inhibitory effect.

This Article

  1. Published in Advance December 30, 2009, doi: 10.1261/rna.1838210 RNA 16: 405-416

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