Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes

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FIGURE 9.
FIGURE 9.

Cartoon schematic to show that miR-107 and miR-128 transfections decrease the enrichment of endogenous mRNA targets in AGO-miRNPs. MiR-107 and miR-128 also lead to decreased miRNA/miRNP activity by reporter assays, correlated with decreased AGO mRNA and protein in the cells. However, since AGO mRNAs are not enriched in miRNPs, the mechanism for the down-regulation of AGO is as yet unknown.

This Article

  1. Published in Advance December 30, 2009, doi: 10.1261/rna.1905910 RNA 16: 394-404

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