FIGURE 5.
Quantification of RISC in rat and rhesus monkey. Rats (A) or two rhesus monkeys (B) were treated with a single intravenous dosing of 3.6 mg/kg LNP201b-Ssb siRNA and analyzed at indicated time points. Ssb mRNA expression (left y-axis) relative to housekeeping Ppib was normalized to that of PBS-treated animals (defined as 100%). Levels of siRNA strands (right y-axis) were normalized to those of respective coimmunoprecipitated mir-122. For rats each bar represents the group mean SD (n = 3 per group). For monkeys the data are shown as for the individual animal.
