Intragenic transcription of a noncoding RNA modulates expression of ASP3 in budding yeast

Model for the chromatin status at the ASP3 promoter in the presence and absence of intragenic transcription. The chromatin status in wild-type (left) and iceΔ (right) strains is shown under nitrogen-rich conditions (upper) and under nitrogen starvation (bottom). With the help of intragenic transcription (light-blue lines), the promoter region of ASP3 is immediately accessible for RNAPII upon nitrogen starvation. In the absence of intragenic transcription, the promoter region is more condensed, thus requiring chromatin-remodeling ATPase to enhance the accessibility of this region to RNAPII for ASP3 transcription (red lines) after nitrogen depletion.