FIGURE 1.
PUF proteins bind distinct sites. (A) Hs PUM1; structure of human Pumilio1–RNA complex (PDB accession code 1M8Y) (Wang et al. 2002). Eight RNA-recognition helices (purple in structure, red in diagram) contribute side chains to contact the RNA bases (blue). Hydrogen-bonding interactions are indicated by red lines in the structure; stacking interactions are not shown. (B) Four clusters of C. elegans PUF proteins (Stumpf et al. 2008b). PUF proteins are grouped based on amino acid similarity; known binding sites are indicated for each cluster.
