Co-occupancy of two Pumilio molecules on a single hunchback NRE

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FIGURE 1.
FIGURE 1.

Structure of hb mRNA. (A) Two NREs are located within the 3′ UTR of the hb mRNA. (B) Each NRE contains two Pum binding sites; Box A at the 5′end and Box B at the 3′ end. (C) Crystal structure of human Pum Puf domain (HsPum) bound to a fragment of NRE2 shows 8–10 nt contacting the concave surface of the protein (Wang et al. 2002).

This Article

  1. Published in Advance April 16, 2009, doi: 10.1261/rna.1327609 RNA 15: 1029-1035

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