Structure of the cytosine–cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin

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FIGURE 1.
FIGURE 1.

(A) Secondary structure of the CC mismatch containing mRNA hairpin that binds the enzyme thymidylate synthase. The binding site for the enzyme is the AUG sequence in the loop. (B) Secondary structure of TSMC RNA molecule used in this study. The boxed region shows the sequence important for aminoglycoside binding, common to both constructs.

This Article

  1. Published in Advance March 27, 2009, doi: 10.1261/rna.1514909 RNA 15: 911-922

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