Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing

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FIGURE 8.
FIGURE 8.

Polyadenylation releases EDC-attached mRNA from the polymerase in a process that must be licensed by splicing. The upper pathway in the model shows release from CPA attachment being triggered by polyadenylation. The lower pathway depicts splicing factors constraining the CPA and preventing this release until the splicing factors themselves are ejected by splicing.

This Article

  1. Published in Advance March 20, 2009, doi: 10.1261/rna.1409209 RNA 15: 823-836

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