Genome wide analysis of gene expression reveals specific roles for subunits of the Ccr4-Not complex. Total cellular RNA was extracted from the indicated wild-type or mutant cells growing exponentially or 30 min after glucose depletion (post-diauxic) and was analyzed by micro-array experiments using the Affymetrix system. (A) The number of target genes defined in each case is indicated. (B) Hierarchical clustering of gene expression in exponentially growing cells (left panel) or cells grown to the post-diauxic phase (right panel). Each line represents a gene, and the color value indicates the fold change (in log2 scale) between the mutant and the wild type in the same growth condition, except in the left lane of the left panel, where we show changes in expression of the genome in wild-type cells after the diauxic shift.
