Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 4.
FIGURE 4.

Splicing of designer exons. Bottom: Splicing of 139 designer exons ranked by percent exon inclusion. Exon inclusion is defined as 100 × included/(included + skipped), and the value is the average of at least two independent transfections (average SE = 16%). Top: Structure of the corresponding designer exons. Each colored rectangle represents an E (green) or S (red) module. The 5′ end of the exon is at the bottom. Exon inclusion levels for this designer exon are presented in tabular form in Supplemental Table 1.

This Article

  1. RNA 15: 367-376