FIGURE 1.
Lin28 expression alters cell cycle structure. (A,B) ES cells were transfected with the indicated siRNAs or plasmid DNAs as previously described (Zhang et al. 2007), respectively. Forty-eight hours later, cells were pulse-labeled with BrdU for 1 h and processed for flow cytometric analysis. The percentages of cells in the G1-, S-, or G2/M phase are shown, together with representative dot plots. Values are the mean of two experiments.
