ShapeFinder: A software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis

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FIGURE 4.
FIGURE 4.

Flowchart of the Align and Integrate algorithm, which involves three phases: (1) peak finding and linking of (+) reagent, (−) reagent, and sequencing peaks; (2) peak alignment to the RNA sequence; and (3) calculation of per nucleotide SHAPE reactivities by Gaussian integration.

This Article

  1. Published in Advance September 4, 2008, doi: 10.1261/rna.1166808 RNA 14: 1979-1990

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