A case for “StopGo”: Reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing continued translation (Go)

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FIGURE 1.
FIGURE 1.

Comparison of the genome organization of Perina nuda picorna-like virus (PnPV) and foot and mouth disease virus (FMDV). The protein products of the single open reading frame are shown as separate boxes. The shaded regions were identified by intact or digested protein analysis of PnPV virions. “L” denotes the leader peptide. Regions encoding 2A sequences are overlined and indicated by arrows. Putative virally encoded protease cleavage sites in PnPV are indicated by “*”. Only one of the virally encoded protease cleavage sites, *, is indicated in FMDV. CP1–4 denotes the four PnPV capsid proteins and VP1–4 denotes the four FMDV capsid proteins.

This Article

  1. RNA 13: 803-810