FIGURE 1.
Model of obligatorily coupled bunyavirus transcription and translation. (A) Transcription termination requires RNA interactions involving the termination signal (shown as stop signs) or its complement in mRNA. Translating ribosomes prevent formation of interactions, so termination signals within genome coding regions are suppressed. Termination signals within NTRs are active, as these regions are not translated, thus allowing RNA interactions to form (shown as a loop). (B) When translation is inhibited, RNA interactions can form, thus activating previously silent termination signals within coding regions.
