Elevated FMR1 mRNA in premutation carriers is due to increased transcription

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FIGURE 5.
FIGURE 5.

Graph of the relationship between relative FMR1 mRNA levels, the number of CGG repeats, and the number of AGG interruptions, for a cohort of 128 adult male premutation carriers and controls. Gray circles, 2 AGG interruptions; open circles, 1 AGG; black circles, 0 AGGs. (Inset) Histogram representing the average FMR1 mRNA levels for premutation alleles with 0 AGG interruptions or with 1 AGG interruption (includes two cases with 2 AGGs); error bars represent SEMs.

This Article

  1. Published in Advance February 5, 2007, doi: 10.1261/rna.280807 RNA 13: 555-562

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