Elevated FMR1 mRNA in premutation carriers is due to increased transcription

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FIGURE 4.
FIGURE 4.

Expansion of the CGG repeat in the FMR1 mRNA does not affect the fraction of message that possesses a 5′ cap. Capped and uncapped mRNAs were fractionated by affinity chromatography (see Materials and Methods); capped and uncapped mRNAs were quantified by TaqMan RT-PCR, using either GUS (A) or GAPDH (B) mRNAs as reference genes.

This Article

  1. Published in Advance February 5, 2007, doi: 10.1261/rna.280807 RNA 13: 555-562

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